The new headline bout comes almost exactly one week after Conor McGregor was pulled from UFC 200.
It was clear that he was the frontrunner to land the headline spot for his rematch with Cormier with the light heavyweight title up for grabs.
The two rivals were supposed to meet at UFC 197 but Cormier suffered a shin injury that forced him out of the fight.
Jones beat Cormier by unanimous decision the last time they met in January 2015.
Jones vs. Cormier 2 becomes the third title fight taking place at UFC 200 in addition to Miesha Tate facing Amanda Nunes as well as Jose Aldo against Frankie Edgar for the interim featherweight title.